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Synthesis of 1-[15N]amino-2-propanol hydrochloride

✍ Scribed by Katsumi Iida; Kuniaki Ohtaka; Masahiro Kajiwara

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
92 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

1‐[^15^N]Amino‐2‐propanol hydrochloride (2) was synthesized in three steps, i.e. Gabriel condensation of potassium [^15^N]phthalimide (3) with chloroacetone (4), reduction of the product ([^15^N]phthalimidoacetone (5)) with sodium borohydride, and hydrolysis in 33% total yield from the ^15^N‐source. Copyright © 2007 John Wiley & Sons, Ltd.

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