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Synthesis of 15N labelledl alkaloids: Coniine−15N and nicotine-1′−15N

✍ Scribed by E. Leete; H. V. Isaacson; H. D. Durst

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
252 KB
Volume
7
Category
Article
ISSN
0022-2135

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✦ Synopsis

Coniine-15N was obtained by the reductive amination of 5-0x0octanal using sodium cyanoborohydride and a m m o n i ~m -~~N bromide. Nornicotine-l'-15N resulted from a similar reductive aminution of 4-oxo-4-(3'-pyridyl)butanal. Merhybtion with formaldehyde and ,formic acid afforded n i ~o t i n e -I ' -~~N .

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