✦ LIBER ✦

A convenient synthesis of creatine-15N from glycine-15N via sarcosine-15N

✍ Scribed by W. Greenaway; F. R. Whatley

Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 184 KB
Volume: 14
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580140417

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✦ Synopsis

The pre aration of creatine-' 5N monohydrate from intermediate is described.

15N) is converted to benzenesulphonyl glycine-I 5N, which is methylated to give benzenesulphonyl sarcosine--l5N. The latter is hydrolysed to sarcosine-l 5N1 which is isolated by ion exchange chromatography. Sarcosine-l5N is converted to creatine-l5N monohydrate by reaction with cyanamide in aqueous solution in the presence of sodium chloride and catalytic amounts of ammonium hydroxide-14N. The creatine-15N monohydrate precipitated from the above reaction mix is recrystallized from boiling water. The yield of sarcosine-15N from glycine-15N is 78% of theory and that of recrystallized creatine-15N monohydrate from glycine-15N is 59% of theory.

glycine-1 F N with the isolation of sarcosine-15N as an Glycine-15N (97.3 atom%

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