✦ LIBER ✦
Convenient preparation of Boc-L-[4-15N]asparagine and -[5-15N]glutamine for application in peptide synthesis
✍ Scribed by Leszek Lankiewicz; Leif Grehn; Ulf Ragnarsson
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 253 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The title compounds have been prepared by a simple and economical procedure from the corresponding Bocprotected α‐benzyl esters and [^15^N]ammonia with N,N′‐carbonyldiimidazole as coupling agent. Catalytic hydrogenolysis furnished both labelled products in high overall yields suitable for synthetic work.