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Syntheses of [1-15N]-2′-Deoxyinosine, [4-15N]-2′-DeoxyAICAR, and [1-15N]-2′-Deoxyguanosine

✍ Scribed by Bruno Catalanotti; Lorenzo De Napoli; Aldo Galeone; Luciano Mayol; Giorgia Oliviero; Gennaro Piccialli; Michela Varra

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
158 KB
Volume
1999
Category
Article
ISSN
1434-193X

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✦ Synopsis

A high-yield synthesis of [1-15 N]-2Ј-deoxyinosine ( 5), [4-counterpart, through [1-15 N]-2Ј-deoxyinosine (5), and successively, [4-15 N]-2Ј-deoxyAICAR ( 7).

[1-15 N]-2Ј-15 N]-2Ј-deoxyAICAR (7), and [1-15 N]-2Ј-deoxyguanosine (10) from 2Ј-deoxyinosine (1) using relatively low expensive Deoxyguanosine (10) can be prepared as well, through an improved cyclization procedure. No protection of sugar 15 NH 3 as 15 N source is described. The method exploits 2-C reactivity of 2Ј-deoxyinosine (1) to obtain its 15 N-labelled hydroxyl groups is required at any stage.

📜 SIMILAR VOLUMES

The first synthesis of [9, amino-15N2] a
The first synthesis of [9, amino-15N2] adenine and β-2′-deoxy-[9, amino-15N2] adenosine
✍ Charles C. Orji; Louis A. Silks III 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 290 KB 👁 1 views

~-2'-Deoxy-[9,Amino-~~N~]Adenosine has been constructed in 4 steps from commercially available 5-amino-4,6-dichloropyrirnidine and 15NH3. The reactions have been scaled to provide significant quantities of labeled nucleoside.