Synthesis of 1-11C-labeled fatty acid from [11C]HCN
β Scribed by Toshihiro Takahashi; Tatsuo Ido; Kentaro Hatano; Ren Iwata; Hiroaki Nakanishi
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 535 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0883-2889
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π SIMILAR VOLUMES
The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration o
Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.
1 1C]-Methylchloroformate, a novel [ 1 lcl-acylating agent, was generated in situ from [11C]-methanol and phosgene. To explore the utility of [11C]-methylchloroformate, this agent was reacted with several amines to yield their corresponding [I 1C]-labeled methylcarbamates. The average synthesis (inc