✦ LIBER ✦

Optimization of [11C]HCN production and no-carrier-added [1-11C]amino acid synthesis

✍ Scribed by Ren Iwata; Tatsuo Ido; Toshihiro Takahashi; Hiroaki Nakanishi; Shigenori Iida

Publisher: Elsevier Science
Year: 1987
Weight: 514 KB
Volume: 38
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(87)90003-7

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✦ Synopsis

The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration of 5 vol%, a Pt furnace temperature of 920 degrees C, and a reaction gas flow rate of over 200 mL/min. Absorbers were used to remove O2 and H2O from the reaction gas. The synthesis of no-carrier-added [1-11C]amino acids from [11C]HCN via [11C]aminonitriles was successfully carried out. This method is suitable for automation of [1-11C]amino acid production.

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