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Synthesis of no carrier added [1-11C]propenoic acid and derivatives

✍ Scribed by M.C. Lasne; Ph. Cairon; L. Barre

Publisher: Elsevier Science
Year: 1992
Weight: 476 KB
Volume: 43
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(92)90030-i

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✦ Synopsis

The reproducible preparation of [1-11C]propenoic acid (acrylic acid) in 45-50% radiochemical yield was made possible by careful control of the temperature and time of the 11C carbonation of ethenylmagnesium bromide. It allowed the obtention of [1-11C]propenoyl chloride and N-[1-11C] substituted propenamides. These latter were highly reactive as it was shown by the obtention of a Michael adduct with secondary amines even at room temperature.

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