Automated no-carrier-added synthesis of [1-11C]-labeled d- and l-enantiomers of lactic acid
✍ Scribed by Konstantin Drandarov; P. August Schubiger; Gerrit Westera
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 355 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0969-8043
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📜 SIMILAR VOLUMES
The reproducible preparation of [1-11C]propenoic acid (acrylic acid) in 45-50% radiochemical yield was made possible by careful control of the temperature and time of the 11C carbonation of ethenylmagnesium bromide. It allowed the obtention of [1-11C]propenoyl chloride and N-[1-11C] substituted prop
The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration o
## Abstract The synthesis of 1‐ and 3‐^11^C‐labelled L‐lactic acid from the corresponding racemic 1‐ or 3‐^11^C‐labelled alanine using a multi‐enzymatic reaction route, is presented. DL‐[1‐^11^C]Alanine was synthesised by reacting sodium 1‐hydroxy‐ethyl sulfite with hydrogen [^11^C]cyanide, obtaine
## Abstract D,L‐3‐[^11^C]‐Alanine was prepared by methylation with ^11^CH~3~I of tert butyl 2‐isocyanoacetate and subsequent hydrolysis. Enzymatic reaction using glutamate pyruvate transaminase and lactate dehydrogenase in a coupled reaction yields L‐3‐[^11^C]‐lactic acid. The radiochemical yield i
## Abstract An ^123^I labeled cocaine analog, 4′‐[^123^I]iodococaine, has been prepared by oxidative destannylation of the tributyltin analog and shown to interact with cocaine binding sites in rat brain striatal membranes. It may thus be a suitable SPECT radiotracer for studies of the dopamine reu