An alternative synthesis of DL-[1-11C]Alanine from [11C]HCN
✍ Scribed by Toshihiro Takahashi; Kjell Någren; Kimmo Aho
- Publisher
- Elsevier Science
- Year
- 1990
- Weight
- 311 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0883-2889
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The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration o
A method for the preparation of [1-11C]D-glucose (III) and [1-11C] D-mannose (IV) from [11C] nitromethane is described. [11C]Nitromethane was produced using the on-line method from [11C]methyl iodide. The condensation of no-carrier-added or carrier-added [11C]nitromethane with D-arabinose to form th
## Abstract A method to prepare [1‐^11^C]propyl iodide and [1‐^11^C]butyl iodide from [^11^C]carbon monoxide via a three step reaction sequence is presented. Palladium mediated formylation of ethene with [^11^C]carbon monoxide and hydrogen gave [1‐^11^C]propionaldehyde and [1‐^11^C]propionic acid.