C-a 1 k y 1 i o d i d e s f o l l o w e d b y a c i d i c h y d r o l y s i s a n d t h e l a b e l l e d a m i n o a c i d s w e r e o b t a i n e d i n 1 0 -5 5 X r a d i o c h e m i c a l y i e l d . L-C3-"C+ A L a n i n e a n d L -C 3 -1 1 C l p h e n y l a l a n i n e w e r e o b t a i n e d i
Syntheses of racemic [1-11C]-alanine and partially resolved [3-11C]-alanine
✍ Scribed by B. Långström; B. Stridsberg
- Publisher
- Elsevier Science
- Year
- 1979
- Weight
- 226 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0020-708X
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📜 SIMILAR VOLUMES
## Abstract D,L‐3‐[^11^C]‐Alanine was prepared by methylation with ^11^CH~3~I of tert butyl 2‐isocyanoacetate and subsequent hydrolysis. Enzymatic reaction using glutamate pyruvate transaminase and lactate dehydrogenase in a coupled reaction yields L‐3‐[^11^C]‐lactic acid. The radiochemical yield i
## Abstract Alkylation of ethyl 2‐(2,2,5,5‐tetramethyl‐[1,2,5,]azadisilolidine‐1‐yl)propionate with [^11^C]CH~3~I afforded, following acid hydrolysis and chromatographic purification, the non‐physiological α‐[3‐^11^C]aminoisobutyric acid within 40 min in yields of 5 ‐ 15% (not corrected for decay)