✍ Scribed by Gunnar Antoni; Bengt Långström
No coin nor oath required. For personal study only.
C-a 1 k y 1 i o d i d e s f o l l o w e d b y a c i d i c h y d r o l y s i s a n d t h e l a b e l l e d a m i n o a c i d s w e r e o b t a i n e d i n 1 0 -5 5 X r a d i o c h e m i c a l y i e l d . L-C3-"C+ A L a n i n e a n d L -C 3 -1 1 C l p h e n y l a l a n i n e w e r e o b t a i n e d i n 9 9 X e na n t i o m e r i c e x c e s s a f t e r t r e a t m e n t o f t h e c o r r e s p o n d i n g r a c em i c m i x t u r e b y D -a m i n o a c i d o x i d a s e i m m o b i l i z e d on g l u t a r a ld e h y d e -a c t i v a t e d g l a s s b e a d s . I n a t y p i c a l r u n s t a r t i n g w i t h 1 2 0 m C i C " C 3 c a r b o n d io x i d e , 2 5 m C i C 1 -l l C l b e n z y l i o d i d e was p r e p a r e d a n d u s e d t o g i v e 6 m C i o f D L -C 3 -1 1 C l p h e n y l a l a n i n e w i t h i n 5 0 m i n u t e s . F o l l o w i n g t r e a t m e n t w i t h D -a m i n o a c i d o x i d a s e , 0.3 m C i o f L -C 3 -1 1 C l p h e n y l a l a n i n e was o b t a i n e d a f t e r a t o t a l s y n t h e s i s t i m e o f a b o u t 1 0 0 m i n u t e s . 11 K e y w o r d s : C3-C l -l a b e l l e d a m i n o a c i d s , L-C3-"CIp h e n y l a l a n i n e , L -C 3 -I 1 C l a l a n i n e .
📜 SIMILAR VOLUMES
## Abstract D,L‐3‐[^11^C]‐Alanine was prepared by methylation with ^11^CH~3~I of tert butyl 2‐isocyanoacetate and subsequent hydrolysis. Enzymatic reaction using glutamate pyruvate transaminase and lactate dehydrogenase in a coupled reaction yields L‐3‐[^11^C]‐lactic acid. The radiochemical yield i
The synthesis of C3-1 lClphenylpyruvic acid, starting with 11C02, is reported. This a-keto acid was prepared via a condensation reaction, using C 1 'Clbenzaldehyde (prepared as described elsewhere), and 2-phenyl-5-oxazolone, using diazabicyclooCtane (DABCO) da a base. The condensation product , [a-l
## Abstract The synthesis of 1‐ and 3‐^11^C‐labelled L‐lactic acid from the corresponding racemic 1‐ or 3‐^11^C‐labelled alanine using a multi‐enzymatic reaction route, is presented. DL‐[1‐^11^C]Alanine was synthesised by reacting sodium 1‐hydroxy‐ethyl sulfite with hydrogen [^11^C]cyanide, obtaine
## Abstract A method for the production of two new carbon‐11 labelled difunctional radiolabelling precursors, [^11^C]diethyl oxalate, 2, and [^11^C]oxalic acid, 3, is described. Methyl chloroformate was reacted with no‐carrier‐added [^11^C]cyanide to generate the intermediate nitrile, methyl [^11^C