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Synthesis of [3-11C]phenylpyruvic acid and its use in an enzymatic transamination to [3-11C]phenylalanine

✍ Scribed by Christer Halldin; Bengt Längström

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
257 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis of C3-1 lClphenylpyruvic acid, starting with 11C02, is reported. This a-keto acid was prepared via a condensation reaction, using C 1 'Clbenzaldehyde (prepared as described elsewhere), and 2-phenyl-5-oxazolone, using diazabicyclooCtane (DABCO) da a base. The condensation product , [a-l 1Cl-4-benzylidene-2-phenyl-5-oxa2010ne, was converted by basic hydrolysis to give C3-1 lClphenylpyruvic acid in 40 % rackochemical yield, starting with within 40 min. The potential of C3-1 'Clphenylpyruvic acid in enzymatic transamination, catalysed by glutamic/oxaloacetic acid transaminase (GOT) (EC 2.6.1.1) immobilized on CNBr-activated Sepharose was also studied. 1 1 COz, Key Words: 'C-phenylpyruvic acid, 'C-phenylalanine , C3-1 lClamino acid, "C-a-keto acid.

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