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An improved synthesis of [24-14C]cholic acid, and its application to the synthesis of [14C]SCH 209702 (Syn3). Synthesis of [2H8]SCH 209702

✍ Scribed by Sumei Ren; Paul McNamara; David Koharski

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
133 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient synthesis of [24‐^14^C]cholic acid from potassium [^14^C]cyanide has been developed. The key intermediate, 23‐chloro‐3α, 7α, 12α‐triformyloxynorcholane, was synthesized by degradation of triformyl protected cholic acid. Different degradation conditions were explored. The synthesis of [^14^C]SCH 209702 from 23‐chloro‐3α, 7α, 12α‐triformyloxynorcholane and potassium [^14^C]cyanide is described. The synthesis of [^2^H~8~]SCH 209702 from [^2^H~4~]cholic acid is also presented. Copyright © 2008 John Wiley & Sons, Ltd.

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