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Preparation of α–[3-11C]aminoisobutyric acid from an azadisilolidine derivative of alanine

✍ Scribed by Franz Oberdorfer; Axel Zobeley; Klaus Weber; Christian Prenant; Uwe Haberkorn; Wolfgang Maier-Borst

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
415 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Alkylation of ethyl 2‐(2,2,5,5‐tetramethyl‐[1,2,5,]azadisilolidine‐1‐yl)propionate with [^11^C]CH~3~I afforded, following acid hydrolysis and chromatographic purification, the non‐physiological α‐[3‐^11^C]aminoisobutyric acid within 40 min in yields of 5 ‐ 15% (not corrected for decay) related to initially produced [^11^C]CH~3~I. Usually 1.2·10^9^ Bq of the tracer molecule were prepared for use in amino acid transport studies. Dilution with a known amount of unlabelled α‐aminoisobutyric acid (10 μmol) provided a constant specific radioactivity of 1.2·10^8^ Bq·μmol^−1^ for each application. The radiochemical purity of that product was better than 98%, whereas the final carrier‐added solution typically contained 10 ‐ 45 μmol of alanine.

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