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Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide

✍ Scribed by Siya Ram; Leonard D. Spicer

Publisher: Elsevier Science
Year: 1989
Weight: 215 KB
Volume: 40
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(89)90207-4

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✦ Synopsis

Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.

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