Preparation of [11C]carbon dioxide from [11C]cyanide
β Scribed by Thomas E. Boothe; Ronald D. Finn; Paresh J. Kothari; Ali M. Emran
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 252 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
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π SIMILAR VOLUMES
Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.
## Abstract A synthetic strategy for producing new difunctional molecules for potential use as radiolabelling precursors derived from [^11^C]cyanide is presented. Noβcarrierβadded [^11^C]CN^β^ was reacted with chloromethyl pivalate to generate the nitrile [^11^C]cyanomethyl pivalate, which was subs