Difunctional two-carbon molecules derived from [11C]cyanide

✍ Scribed by Jan-Olov Thorell; Sharon Stone-Elander; Nils Elander

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 342 KB
• Volume: 34
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580340410

✦ Synopsis

Abstract

A synthetic strategy for producing new difunctional molecules for potential use as radiolabelling precursors derived from [^11^C]cyanide is presented. No‐carrier‐added [^11^C]CN^−^ was reacted with chloromethyl pivalate to generate the nitrile [^11^C]cyanomethyl pivalate, which was subsequently converted to ethyl 1 [1‐^11^C]glycolate, 2, with acid and alcohol, or to [1‐^11^C]glycolic acid, 4, using aqueous acid. [1‐^11^C]Ethylene glycol, 3, and [2‐^11^C]2‐aminoethanol 5, were obtained by reduction of2 and 1, respectively, with lithium aluminum hydride. Conditions for obtaining conversions ca. 90% are described. By using a microwave wave‐guide cavity to speed up transformations requiring elevated temperatures, all five carbon‐11 labelled compounds were synthesized in less than a total of 3 min.