A [11C]carbon dioxide generator
โ Scribed by Perry S. Kruijer; Jacobous D.M. Hescheid
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 137 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0969-8043
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Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.
Although production methods of short-lived radioactive gfQes were established more than ten years ago, production of CO seems tolgtill have a probl . The conventional method to produce 2 difficulty in temperature control because reduction temperature (390OC or higher) is nefy to the melting point of
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