Synthesis and biodistribution of 11C labelled unsaturated fatty acids
โ Scribed by J-L. Piette; M.C. Pardon; G. Delfiore; L. Quaglia; J-M. Peters; C. De Landsheere; P. Rigo
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 92 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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๐ SIMILAR VOLUMES
A synthetic procedure for producing isotopically a-labelled fatty acids is described. The isotopic label is introduced by reducing an a-tosylate with either labelled sodium borohydride or labelled lithium dimethyl cuprate.
## Abstract SNโ38 (7โethylโ10โhydroxy camptothecin) is a topoisomerase I inhibitor that is the active chemotherapeutic agent of irinotecan, indicated for colon cancer. Because the rate of response to irinotecan treatment is low, it is of interest to have a prognostic indicator to identify and more
## Abstract We report the synthesis of ^11^Cโlabelled choline using the reaction of โnocarrierโaddedโ ^11^Cโlabelled methyliodide and 2โaminoโ(N,Nโdimethyl)โethanol. After determining the optimum temperature and duration for the reaction, we achieved a radiochemical yield of about 30% and the radio