A synthetic procedure for producing isotopically a-labelled fatty acids is described. The isotopic label is introduced by reducing an a-tosylate with either labelled sodium borohydride or labelled lithium dimethyl cuprate.
Synthesis of cholesteryl esters of labelled fatty acids
โ Scribed by A. K. Grover; R. J. Cushley
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- French
- Weight
- 291 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract A simplified procedure is described for the synthesis and purification of labelled cholesteryl esters. The esters are synthesized enzymatically from (4โ^14^C) cholesterol and free fatty acids. The separation of the lipids from aqueous medium is simplified by lyophilizing the reaction m
High specific activity methyl-butyrate-2,3-H3 and methyl-stearate-9,lO-H3 were stored for approximately three months. The self-radiolysis decomposition products were identified by means of radio-gas chromatographic methods and the isotopic dilution technique. Rather high G-values were found for the
## Abstract Four ^123m^Te labeled fatty acid analogues were synthesized: 17โtelluraโ9โoctadecenoic acid, 17โtelluraโ9โnonadecenoic acid, 18โmethylโ17โtelluraโ9โnonadecenoic acid and 3โtelluraโnonโadecanoic acid. Telluriumโ123m metal was solubilized in water with NaBH~4~. The inorganic nucleophiles