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Synthesis of 123mTe labeled fatty acids

✍ Scribed by Stanley L. Mills; Garo P. Basmadjian; George R. Parker; Rodney D. Ice

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 396 KB
Volume: 18
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580180514

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Four ^123m^Te labeled fatty acid analogues were synthesized: 17‐tellura‐9‐octadecenoic acid, 17‐tellura‐9‐nonadecenoic acid, 18‐methyl‐17‐tellura‐9‐nonadecenoic acid and 3‐tellura‐non‐adecanoic acid.

Tellurium‐123m metal was solubilized in water with NaBH~4~. The inorganic nucleophiles produced, NaHTe or Na~2~Te~2~ were reacted with 16‐bromo‐9‐hexadecenoic acid in a one or two step procedure to produce the sodium alkyl telluride. To this was added either methyl iodide, ethyl bromide or isopropyl bromide and the resulting 17‐tellura‐fatty acids isolated and formulated. Tellurium‐123m labeled 3‐tellura‐nonadecanoic acid was synthesized via the dihexadecanyl ditelluride or the sodium hexadecanyl telluride route.

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