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A simplified biological synthesis of labeled cholesteryl esters

✍ Scribed by Himanshu V. Kothari; Janet S. Carlton; David Kritchevsky

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
206 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A simplified procedure is described for the synthesis and purification of labelled cholesteryl esters. The esters are synthesized enzymatically from (4‐^14^C) cholesterol and free fatty acids.

The separation of the lipids from aqueous medium is simplified by lyophilizing the reaction mixture at equilibrium. The lipid components of the freeze‐dried powder are separated by silicic acid chromatography. The radiochemical purity of the product was shown to be greater than 98%.

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