๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis and Structural Proof of a Potent 5-Lipoxygenase Inhibitor

โœ Scribed by Devipriya Balu; Kumaradhas Poomani; Kalyanam Nagabushanam; Sridhar Balasubramanium; Rajendran Ramanujam; Majeed Muhammed


Publisher
Springer
Year
2011
Tongue
English
Weight
478 KB
Volume
41
Category
Article
ISSN
1572-8854

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Synthesis of CMI-97
โœ Xiong Cai; Mukund S. Chorghade; Aberra Fura; Gurmit S. Grewal; Karen A. Jauregui ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 1 views

Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-ฮณ-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,

Cmi-206: A potent dual platelet activati
โœ Md. Sajjat Hussoin; Xiong Cai; Ralph T. Scannell; David Yaeger; David B. Killian ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 310 KB

-propoxy-S(N'-butyl-N'-hydroxyureidyl)phenyl]-S-(3,4.5-trimethoxyphenyl)tetrahydrofuran, was synthesized and was found to antagonize PAP receptor binding and inhibit S-lipoxygenase activity both in vitro and in vivo.

Synthesis of A-79175: a second generatio
โœ Daniel A. Dickman; Yi-Yin Ku; Howard E. Morton; Sanjay R. Chemburkar; Hemantkuma ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 303 KB

A convergent, high yielding, and scalable synthesis of A-79175, with a key step involving a mild and efficient Cu-Pd catalyzed coupling reaction of a terminal acetylene with a substituted 2-iodofuran is discussed.