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A novel series of highly potent 5-lipoxygenase inhibitors; 2-aryldienylbenzoxazoles

✍ Scribed by Takatoshi Kosaka; Keiko Ochiai; Setsuya Ohba; Toshio Wakabayashi; Sei-itsu Murota


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
193 KB
Volume
5
Category
Article
ISSN
0960-894X

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Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-Ξ³-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,