ChemInform Abstract: Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor.

✍ Scribed by Xiong Cai; Mukund S. Chorghade; Aberra Fura; Gurmit S. Grewal; Karen A. Jauregui; Heather A. Lounsbury; Ralph T. Scannell; C. Grace Yeh; Michelle A. Young; Shaoxia Yu

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199919124

✦ Synopsis

Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor.

-A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-γ-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,