ChemInform Abstract: A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977.
β Scribed by Darren J. Dixon; Steven V. Ley; Dominic J. Reynolds; Mukund S. Chorghade
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-Ξ³-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,
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