✦ LIBER ✦

Synthesis of A-79175: a second generation 5-lipoxygenase inhibitor

✍ Scribed by Daniel A. Dickman; Yi-Yin Ku; Howard E. Morton; Sanjay R. Chemburkar; Hemantkumar H. Patel; Albert Thomas; Daniel J. Plata; David P. Sawick

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 303 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00159-6

No coin nor oath required. For personal study only.

✦ Synopsis

A convergent, high yielding, and scalable synthesis of A-79175, with a key step involving a mild and efficient Cu-Pd catalyzed coupling reaction of a terminal acetylene with a substituted 2-iodofuran is discussed.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of A-7917

ChemInform Abstract: Synthesis of A-79175: A Second Generation 5-Lipoxygenase Inhibitor.

✍ D. A. DICKMAN; Y.-Y. KU; H. E. MORTON; S. R. CHEMBURKAR; H. H. PATEL; A. THOMAS; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB

Synthesis of 5,6-difluoroarachidonic aci

Synthesis of 5,6-difluoroarachidonic acid, a potential inhibitor of 5-lipoxygenase

✍ Sylvia Bildstein; Jean-Bernard Ducep; Detlef Jacobi; Pascale Zimmermann 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 150 KB

ChemInform Abstract: Synthesis of CMI-97

ChemInform Abstract: Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor.

✍ Xiong Cai; Mukund S. Chorghade; Aberra Fura; Gurmit S. Grewal; Karen A. Jauregui 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-γ-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,

The properties of A-69412: A small hydro

The properties of A-69412: A small hydrophilic 5-lipoxygenase inhibitor

✍ R. L. Bell; J. Bouska; P. R. Young; C. Lanni; J. Machinist; P. E. Malo; J. B. Su 📂 Article 📅 1993 🏛 SP Birkhäuser Verlag Basel 🌐 English ⚖ 614 KB

CGS 22745: A selective orally active inh

CGS 22745: A selective orally active inhibitor of 5-lipoxygenase

✍ E. Kimble; T. Kowalski; D. White; A. Raychauduri; G. Pastor; H. Chertock; W. Lee 📂 Article 📅 1991 🏛 SP Birkhäuser Verlag Basel 🌐 English ⚖ 244 KB

A Facile Synthesis of 2-Acyl and 2-Alkyl

A Facile Synthesis of 2-Acyl and 2-Alkylaminobenzimidazoles for 5-Lipoxygenase Inhibitors.

✍ Jin Ha Lee; Mi Hyun An; Eun Hyun Choi; Hea-Young Park Choo; Gyoonhee Han 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views