Synthesis of 5,6-difluoroarachidonic acid, a potential inhibitor of 5-lipoxygenase
β Scribed by Sylvia Bildstein; Jean-Bernard Ducep; Detlef Jacobi; Pascale Zimmermann
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 150 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Syntheses of 7,7-and 10,10-dimethyleicosa-5(Z1,8(Z),ll(Z1-trienoic acids (zand $1, which possess 5-lipoxygenase inhibitory activity, are described. Arachidonic acid (L) is now well established as a key substance in the biosynthesis of the leukotrienes, a family of compounds that have been implicated
A convergent, high yielding, and scalable synthesis of A-79175, with a key step involving a mild and efficient Cu-Pd catalyzed coupling reaction of a terminal acetylene with a substituted 2-iodofuran is discussed.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The preparation of hydroxylamine analogs of 2,6-di-tert-butylphenols (DTBP) and the inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) by these compounds is discussed.
Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. -A facile large-scale synthesis of the potent 5-lipoxygenase inhibitor CMI-977 (XI) in enantiomerically pure form starting from hydroxymethyl-Ξ³-butyrolactone (I) derived from (S)-glutamic acid is described (yields given in g). -(CAI,