Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor

✍ Scribed by Md. Sajjat Hussoin; Xiong Cai; Ralph T. Scannell; David Yaeger; David B. Killian; Joseph Eckman; San-Bao Hwang; Lynn Libertine-Garahan; Changgeng Qian; C. Grace Yen; Stephen Ip

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 310 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00088-b

✦ Synopsis

-propoxy-S(N'-butyl-N'-hydroxyureidyl)phenyl]-S-(3,4.5-trimethoxyphenyl)tetrahydrofuran, was synthesized and was found to antagonize PAP receptor binding and inhibit S-lipoxygenase activity both in vitro and in vivo.