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Synthesis and stability of S-(2-[18F]fluoroethyl)-L-homocysteine for potential tumour imaging

✍ Scribed by Thomas Bourdier; Christopher J. R. Fookes; Tien Q. Pham; Ivan Greguric; Andrew Katsifis

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
167 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The F‐18 labelled methionine derivative S‐(2‐[^18^F]fluoroethyl)‐L‐homocysteine ([^18^F]FEHCys) was prepared by a one‐pot two‐step synthesis via the protected S‐(2‐bromoethyl)‐L‐homocysteine 1 and S‐(2‐chloroethyl)‐L‐homocysteine 2 precursors. The bromoethyl derivative 1 gave higher radiochemical yields (40% at 5 min) at 100°C compared with the chloro‐analogue (22% at 100°C in 30 min). However, [^18^F]FEHCys was found to be unstable in aqueous systems being transformed to the corresponding hydroxyl derivative within 20 min. Copyright © 2008 John Wiley & Sons, Ltd.

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