✦ LIBER ✦

Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

✍ Scribed by Andrew G. Horti; Hayden T. Ravert; William B. Mathews; Edward H. Abraham; Richard L. Wahl; Robert F. Dannals

Publisher: John Wiley and Sons
Year: 2006
Tongue: French
Weight: 107 KB
Volume: 49
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1097

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✦ Synopsis

2-[ 18 F]fluoroadenosine (2-[ 18 F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[ 18 F]FAD were 5%, 22-30 mCi/mmol and 99%, and 0.5%, 1200-1700 mCi/mmol and 99%, respectively.

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