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Rapid and efficient synthesis of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides as potential pet radiopharmaceuticals for melanoma imaging

✍ Scribed by I. Al Jammaz; B. Al-Otaibi; S. Okarvi; J. Amartey

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
187 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

In an attempt to simplify nucleophilic radiofluorination reactions to be amenable for automation, a series of [^18^F]fluoronicotinamides, [^18^F]fluoroisonicotinamides and [^18^F]fluorobenzamides were synthesized using one‐step synthetic approach involving displacement reactions on trimethylammonium‐nicotinamide, trimethylammonium‐isonicotinamide and trimethylammonium‐benzamide precursors. Based on starting [^18^F]‐fluoride, radiochemical yields and purities were found to be greater than 90 and 97%, respectively, within 20 min synthesis time and, without high‐performance liquid chromatography purification. This synthetic approach holds great promise as a rapid and simple method for the automated radiofluorination of [^18^F]fluoronicotinamides, [^18^F]fluoroisonicotinamides and [^18^F]fluorobenzamides with high radiochemical yield and very short preparation time. Copyright © 2011 John Wiley & Sons, Ltd.

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