𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of [18F]Fluoroclofilium as a potential cardiac imaging agent for PET studies

✍ Scribed by K. H. Yu; Y. S. Kim; S. W. Kim; J. H. Park; S. D. Yang; W. Herdering; A. Knoechel

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
128 KB
Volume
46
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

N‐4‐(4‐chlorophenyl)butyl‐N,N‐diethyl‐7‐[^18^F]fluoroheptylammonium ([^18^F]‐fluoroclofilium) has been prepared as a potential cardiac imaging agent. For the synthesis of this radiolabelled ammonium salt, its tosyloxylated analogue was prepared as a precursor, and the non‐radioactive fluorine analogue was synthesized as a reference compound. Radiofluorination was achieved by the treatment of N‐4‐(4‐chlorophenyl)butyl‐N,N‐diethyl‐7‐(p‐toluenesulfonyloxy)heptylammonium p‐toluenesulfonate with ^18^F^−^ in the presence of Kryptofix‐2.2.2 in acetonitrile. Copyright © 2003 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Synthesis of [18F]-labeled adenosine ana
Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
✍ Mian M. Alauddin; John D. Fissekis; Peter S. Conti 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 124 KB

## Abstract __The__ syntheses of adenosine analogues, 2′‐deoxy‐2′‐[^18^F]fluoro‐9‐β‐D‐arabinofuranosyladenine ([^18^F]‐FAA) and 3′‐deoxy‐3′‐[^18^F]fluoro‐9‐β‐D‐xylofuranosyladenine ([^18^F]‐FXA) are reported. Adenosine (**1**) was converted to its methoxytrityl derivatives **2** and **3** as a mixt

Synthesis of a [18F]fluorobenzothiazole
Synthesis of a [18F]fluorobenzothiazole as potential amyloid imaging agent
✍ Ursula Berndt; Christian Stanetty; Thomas Wanek; Claudia Kuntner; Johann Stanek; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 266 KB

## Abstract This study describes the synthesis of a fluoroethylated derivative of [__N__‐methyl‐^11^C]2‐(4′‐methylaminophenyl)‐6‐hydroxybenzothiazole ([^11^C]6‐OH‐BTA‐1; Pittsburgh Compound B (PIB)), an already established amyloid imaging agent. The [^11^C]methylamino group of [^11^C]6‐OH‐BTA‐1 was

Synthesis of 18F-labeled cyclooxygenase-
Synthesis of 18F-labeled cyclooxygenase-2 (COX-2) inhibitor as a potential PET imaging agent
✍ Haibin Tian; Zhenghong Lee 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 144 KB

A new PET tracer for COX-2 imaging, the 6-ethoxy-3-(4-methanesulfonylphenyl)-4-(4-[ 18 F]fluorophenyl)pyran-2-one ([ 18 F]EFMP), was synthesized. For F-18 radiolabeling, a trimethylammonium precursor and a brominated precursor were synthesized from 1,1,2,3-tetrachlorocycloprop-2-ene in 6 steps. The

N1'-(p-[18F]Fluorobenzyl)naltrindole (p-
N1'-(p-[18F]Fluorobenzyl)naltrindole (p-[18F]BNTI) as a potential PET imaging agent for DOP receptors
✍ Eyup Akgün; Munawwar Sajjad; Philip S. Portoghese 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 155 KB

The N1'-(p-fluorobenzyl)naltrindole 5 has been synthesized by reaction of 3-O-benzyl NTI 3 with p-fluorobenzylbromide under phase transfer catalysis. The subsequent 3-O-benzyldeprotection of 4 in HBr/CH 3 COOH gave the target compound 5 in three steps from naltrindole 2. p-FBNTI 5 is a novel delta o