𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 2-[(2-chloro-2′-[18F]fluoroethyl)amino]-2H-1,3,2-oxazaphosphorinane-2-oxide (18F-fluorocyclophosphamide), a potential tracer for breast tumor prognostic imaging with PET

✍ Scribed by Goran Lacan; Amanda L. Kesner; Anne Gangloff; Lei Zheng; Johannes Czernin; William P. Melega; Daniel H. S. Silverman

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
116 KB
Volume
48
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A fluorine‐18 labeled analog of the widely used chemotherapeutic agent cyclophosphamide was synthesized as a tracer for prognostic imaging with positron emission tomography. 2‐[(2‐Chloro‐2′‐[^18^F]fluoroethyl)amino]‐2H‐1,3,2‐oxazaphosphorinane‐2‐oxide (^18^F‐fluorocyclophosphamide), was prepared by direct halogen exchange reaction from the parent cyclophosphamide. In small‐scale syntheses, radiochemical yields of up to 4.9% and specific activities of 960 Ci/mmol were achieved in a total synthesis time of 60–75 min. The [^18^F]‐labeled cyclophosphamide analog with radioactive purity >99% and chemical purity >96% was suitable for in vivo (microPET imaging) and ex vivo studies of a murine model of human breast tumors. Copyright © 2005 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Synthesis of [18F]3-[1-(3-fluoropropyl)-
Synthesis of [18F]3-[1-(3-fluoropropyl)-(S)-pyrrolidin-2-ylmethoxy]pyridine ([18F]NicFP): a potential α4β2 nicotinic acetylcholine receptor radioligand for PET
✍ Filip Dumont; Abida Sultana; Andrew Balter; Rikki N. Waterhouse 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 102 KB

Nicotinic acetylcholine receptors are widely distributed throughout the human brain and are believed to play a role in several neurological and psychiatric disorders. In order to identify an effective PET radioligand for in vivo assessment of the a4b2 subtype of nicotinic receptor, we synthesized [

Synthesis of 6-chloro-3-((2-(S)-azetidin
Synthesis of 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-[18F]fluoropyridin-4-yl)pyridine ([18F]NIDA 522131), a novel potential radioligand for studying extrathalamic nicotinic acetylcholine receptors by PET
✍ Yi Zhang; Andrew G. Horti 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 99 KB

## Abstract 6‐Chloro‐3‐((2‐(__S__)‐azetidinyl)methoxy)‐5‐(2‐[^18^F]fluoropyridin‐4‐yl)pyridine ([^18^F]NIDA 522131), a potential radioligand for studying extrathalamic nicotinic acetylcholine receptors by positron‐emission tomography, was synthesized via no‐carrier‐added nucleophilic [^18^F]fluorin

The synthesis of a new probe for PET ima
The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-amino-6-[18F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)
✍ Hancheng Cai; Duanzhi Yin; Lan Zhang; Yongxian Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

The one step radiosynthesis of 2-amino-6-[ 18 F]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[ 18 F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[ 18 F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [ 18 F]KF and isolated by a silica Sep-Pak cartridge. Th

Synthesis of N-(piperidin-1-yl)-5-(4-met
Synthesis of N-(piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2-chlorophenyl)-4-[18F]fluoro-1H-pyrazole-3-carboxamide by nucleophilic [18F] fluorination: a PET radiotracer for studying CB1 cannabinoid receptors
✍ Reeti Katoch-Rouse; Andrew G. Horti 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 91 KB

## Abstract The feasibility of nucleophilic displacement of bromide in the 4‐bromopyrazole ring with [^18^F]fluoride has been demonstrated by the synthesis of two radiolabeled compounds: __N__‐(piperidin‐1‐yl)‐5‐(4‐methoxyphenyl)‐1‐(2‐chlorophenyl)‐4‐[^18^F]fluoro‐1__H__‐pyrazole‐3‐carboxamide, ([^