The structure of solanesol has been confirmed by total synthesis starting from trans-geranylacetone. By six successive isoprenoid extensions via the tertiary acetylene carbinols, partial hydrogenation of the triple bond, transformation into the primary bromide and acetoacetic ester synthesis, the al
Synthesen in der Polymyxin-Reihe. 5. Mitteilung. Synthese des cyclischen Decapeptids 8α
✍ Scribed by R. O. Studer; K. Vogler; W. Lergier
- Publisher
- John Wiley and Sons
- Year
- 1961
- Tongue
- German
- Weight
- 701 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
The cyclic decapeptide 8α, another of the four possible structures deduced for the natural polymyxin B~1~ by the usual degradation methods, has been synthesized. It appears not to be identical with polymyxin B~1~ in view of its reduced antibacterial activity in vitro.
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## Abstract The synthesis of an antibiotic substance to which we assign the structure 7α, one of the four possible formulas proposed for natural polymyxin B~1~, is reported. Although both synthetic and the natural product have the same antimicrobial activity towards __Brucella bronchiseptica in vit
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## Abstract The protected pentapeptide formyl‐L‐leucyl‐N^γ^‐benzyloxycarbonyl‐L‐α,γ‐diaminobutyryl‐N^γ^‐benzyloxycarbonyl‐L‐α,γ‐diaminobutyryl‐L‐threonyl‐N^γ^‐benzyloxycarbonyl‐L‐α,γ‐diaminobutyric acid, a sequence which is known to occur in the polymyxins, has been synthesized. Different coupling
## Abstract The protected open decapeptide XIII, related to one of the four possible structures for polymyxin B~1~ has been synthesized by condensing together the pentapeptides 1‐2‐3‐4‐5 and 1′‐2′‐6‐7‐8 using either the azide method or the carbodiimide procedure.
## Abstract (+)‐6‐Methyloctanoic (isopelargonic) acid, the fatty acid component of certain polypeptide antibiotics known as polymyxins, has been synthesized by a new route, starting from (−)‐2‐methylbutanol‐(1). The protected dipeptide N^α^‐(+)‐Isopelargonyl‐N^γ^‐benzyloxycarbonyl‐D‐α,γ‐diaminobuty