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Synthesen in der Polymyxin-Reihe 2. Mitteilung. Synthese eines Dipeptid-Fragmentes mit (+)-Isopelargonsäure

✍ Scribed by K. Vogler; L. H. Chopard-dit-Jean

Publisher
John Wiley and Sons
Year
1960
Tongue
German
Weight
551 KB
Volume
43
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

(+)‐6‐Methyloctanoic (isopelargonic) acid, the fatty acid component of certain polypeptide antibiotics known as polymyxins, has been synthesized by a new route, starting from (−)‐2‐methylbutanol‐(1). The protected dipeptide N^α^‐(+)‐Isopelargonyl‐N^γ^‐benzyloxycarbonyl‐D‐α,γ‐diaminobutyryl‐L‐threonine, corresponding to the side chain of two structures which have been proposed for polymyxin B~1~, was obtained by known peptide coupling methods.

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