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Synthesen in der Polymyxin-Reihe. 7. Mitteilung. Synthese des hochaktiven cyclischen Decapeptids 7α

✍ Scribed by R. O. Studer; W. Lergier; K. Vogler

Publisher: John Wiley and Sons
Year: 1963
Tongue: German
Weight: 411 KB
Volume: 46
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19630460222

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✦ Synopsis

Abstract

The synthesis of an antibiotic substance to which we assign the structure 7α, one of the four possible formulas proposed for natural polymyxin B~1~, is reported. Although both synthetic and the natural product have the same antimicrobial activity towards Brucella bronchiseptica in vitro (plate test), they are not identical, as shown by the lower optical rotation of the synthetic material.

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