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Synthesen in der Polymyxin-Reihe. 3. Mitteilung. Synthese eines verzweigten, geschützten Dekapeptids

✍ Scribed by K. Vogler; P. Lanz; W. Lergier; R. O. Studer

Publisher
John Wiley and Sons
Year
1960
Tongue
German
Weight
657 KB
Volume
43
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The protected open decapeptide XIII, related to one of the four possible structures for polymyxin B~1~ has been synthesized by condensing together the pentapeptides 1‐2‐3‐4‐5 and 1′‐2′‐6‐7‐8 using either the azide method or the carbodiimide procedure.

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enthalt demnach ca. 32% ( + )-Epigriseofulvin und ca. 68% ( + )-Griseofulvin. Aktivitat 4,31 . l o 5 ipm/mM, entsprechend dem Austausch von 1,048 Aquivalenten Methoxyl. Zur Lokalisierung der Aktivitat werden 131 mg des obigen Gemisches in 0,65 ml Eisessig und 0,13 ml 2~ Schwefelsaure bei ca. 98" wa