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Synthesen in der Polymyxin-Reihe 1. Mitteilung. Synthese eines Pentapeptid-Fragmentes

✍ Scribed by K. Vogler; P. Lanz

Publisher
John Wiley and Sons
Year
1960
Tongue
German
Weight
771 KB
Volume
43
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The protected pentapeptide formyl‐L‐leucyl‐N^γ^‐benzyloxycarbonyl‐L‐α,γ‐diaminobutyryl‐N^γ^‐benzyloxycarbonyl‐L‐α,γ‐diaminobutyryl‐L‐threonyl‐N^γ^‐benzyloxycarbonyl‐L‐α,γ‐diaminobutyric acid, a sequence which is known to occur in the polymyxins, has been synthesized. Different coupling methods including the azide route lead to the same end product, with the same optical rotation. We therefore believe our pentapeptide to be optically pure.

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