Structures of topostins, DNA topoisomerase I inhibitors of bacterial origin

✍ Scribed by Takayuki Nemoto; Makoto Ojika; Yoshinori Takahata; Toshiwo Andoh; Youji Sakagami

• Book ID: 104209128
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 654 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)83004-4

✦ Synopsis

Abstmet: The structures of topostins, a novel type of mammalian DNA topoisomerase I inhibitors isolated from the bacterium Flexibucter topostinus sp. nov., have remained unknown. Reexamination of the production of topostins resulted in the isolation of original topostins B (B553 (1) and B567 (2)) and new related compounds named topostins D (D640 (3) and D654 (4)). Their structures, including the absolute stereochemistry. were determined by spectroscopic analyses and chemical degradations. These substances are lipid-containing amino acids and peptides. 0