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ChemInform Abstract: Structures of Topostins, DNA Topoisomerase I Inhibitors of Bacterial Origin.

โœ Scribed by T. NEMOTO; M. OJIKA; Y. TAKAHATA; T. ANDOH; Y. SAKAGAMI

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of Analogues of Topostin B, a DNA Topoisomerase I Inhibitor. Part 3. Improved Synthesis of Topostin B-1 Analogues.
โœ H. FUJIWARA; T. AOYAMA; T. SHIOIRI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB ๐Ÿ‘ 2 views

Total Synthesis of Analogues of Topostin B, a DNA Topoisomerase I Inhibitor. Part 3. Improved Synthesis of Topostin B-1 Analogues. -The key step in the synthesis of the title compounds (VIII) and (IX) is the Horner-Emmons reaction of the aldehydes (V) with the phosphonates (III).