Analogs of topostin B-2, ,an inhibitor of mammalian DNA topoisomerase I, have been synthesized in a convenient manner.
Total synthesis of analogs of topostin B, a DNA topoisomerase I inhibitor. Part 3. Improved synthesis of topostin B-1 analogs
โ Scribed by Hideyasu Fujiwara; Toyohiko Aoyama; Takayuki Shioiri
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 818 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4020
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Total Synthesis of Analogues of Topostin B, a DNA Topoisomerase I Inhibitor. Part 3. Improved Synthesis of Topostin B-1 Analogues. -The key step in the synthesis of the title compounds (VIII) and (IX) is the Horner-Emmons reaction of the aldehydes (V) with the phosphonates (III).
Gangliosides, sialic acid containing glycosphingolipids, are a class of structurally diverse molecules commonly present in vertebrate plasma membranes and especially enriched in nerve tissues\*. These membrane components are thought to be responsible for important physiological activities, and it is