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Total synthesis of analogs of topostin B, A DNA topoisomerase I inhibitor. Part 1. Synthesis of fragments of topostin B-1 analogs

✍ Scribed by Hirohide Noguchi; Toyohiko Aoyama; Takayuki Shioiri


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
979 KB
Volume
51
Category
Article
ISSN
0040-4020

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ChemInform Abstract: Total Synthesis of
✍ H. FUJIWARA; T. AOYAMA; T. SHIOIRI πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 35 KB πŸ‘ 2 views

Total Synthesis of Analogues of Topostin B, a DNA Topoisomerase I Inhibitor. Part 3. Improved Synthesis of Topostin B-1 Analogues. -The key step in the synthesis of the title compounds (VIII) and (IX) is the Horner-Emmons reaction of the aldehydes (V) with the phosphonates (III).