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Synthesis of topostins B567 and D654 (WB-3559D, flavolipin), DNA topoisomerase I inhibitors of bacterial origin

โœ Scribed by Takayuki Shioiri; Yoshihiro Terao; Naoko Irako; Toyohiko Aoyama


Book ID
108379149
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
637 KB
Volume
54
Category
Article
ISSN
0040-4020

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Structures of topostins, DNA topoisomera
โœ Takayuki Nemoto; Makoto Ojika; Yoshinori Takahata; Toshiwo Andoh; Youji Sakagami ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 654 KB

Abstmet: The structures of topostins, a novel type of mammalian DNA topoisomerase I inhibitors isolated from the bacterium Flexibucter topostinus sp. nov., have remained unknown. Reexamination of the production of topostins resulted in the isolation of original topostins B (B553 (1) and B567 (2)) an