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Solid phase synthesis of a self complementary (antiparallel) chiral peptidic nucleic acid strand

✍ Scribed by Alessandro Lenzi; Gianna Reginato; Maurizio Taddei; Elisabeth Trifilieff


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
110 KB
Volume
36
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


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Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA

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The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N 9 -adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (