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Solid-Phase Synthesis of 2,3,5-Trisubstituted 4 H -Imidazolones

✍ Scribed by Yu, Yongping; Ostresh, John M.; Houghten, Richard A.


Book ID
121418628
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
34 KB
Volume
3
Category
Article
ISSN
1520-4766

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Solid phase synthesis of 2,4,5-trisubsti
✍ Adel Nefzi; Marc Giulianotti; Richard A. Houghten πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 170 KB

The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a