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Solid-Phase Synthesis of 1,2,5-Trisubstituted 4-Imidazolidinones

✍ Scribed by Rinnová, Markéta; Vidal, Agnès; Nefzi, Adel; Houghten, Richard A.


Book ID
127357601
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
51 KB
Volume
4
Category
Article
ISSN
1520-4766

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Solid phase synthesis of 2,4,5-trisubsti
✍ Adel Nefzi; Marc Giulianotti; Richard A. Houghten 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 170 KB

The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a