Significance of the parkin gene and protein in understanding Parkinson’s disease
✍ Scribed by Paul S. Fishman; George A. Oyler
- Book ID
- 107543149
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 377 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1528-4042
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic
## Abstract __Parkin__ mutations account for the majority of familial and sporadic early onset Parkinson's disease (EOPD) cases with a known genetic association. More than 100 mutations have been described in the __Parkin__ gene that includes homozygous, compound heterozygous, and single heterozygo