Point mutation in the parkin gene on patients with Parkinson’s disease
✍ Scribed by Wang Tao; Liang Zhihou; Sun Shenggang; Cao Xuebing; Peng Hai; Cao Fei; Liu Hongjin; Tong E-tang
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- Chinese
- Weight
- 369 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0510-9752
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## Abstract A multiethnic series of patients with early‐onset Parkinson's disease (EOP) was studied to assess the frequency and nature of __parkin__/PARK2 gene mutations and to investigate phenotype–genotype relationships. Forty‐six EOP probands with an onset age of <45 years, and 14 affected relat
## Abstract Early‐onset autosomal recessive parkinsonism is associated with parkin gene mutations. Different parkin mutations occur in many ethnic backgrounds; however, the phenotype may vary. We studied 102 young‐onset (age at onset <60 years) Parkinson's disease (PD) patients. From 102 patients,
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